RNAissance Ag Overview
RNAissance Ag is an early-stage US agricultural biotechnology company developing sprayable, RNA interference (RNAi)-based biopesticides. Spun out of the Donald Danforth Plant Science Center in St. Louis and incubated by venture developer TechAccel, it holds an exclusive license to RNAi technology discovered at the Danforth Center and designs double-stranded RNA (dsRNA) molecules that silence essential genes in a single target insect species, aiming to kill the pest while sparing pollinators, beneficial insects, animals and people. Its lead programs have targeted lepidopteran pests — notably diamondback moth and fall armyworm — with Colorado potato beetle among additional targets. Through its 2020 acquisition of RNAgri, it also owns a dsRNA manufacturing platform aimed at the low per-gram cost required for broad-acre spraying. The company is pre-commercial, pre-revenue as far as public sources show, and operates in a nascent category whose first sprayable product (a competitor's) was registered by the US EPA only in December 2023.
What the company does
RNAissance Ag develops topically applied (sprayable) RNAi insecticides. The scientific principle is that a dsRNA molecule, when ingested by an insect, is processed by the insect's own RNAi machinery into small interfering RNAs that suppress expression of a targeted essential gene, leading to feeding cessation and death. Because the sequence is matched to a specific gene in a specific species, the company's products are designed to be highly selective, non-toxic to non-target organisms, and biodegradable. Company releases (October 2022) state that its designs can also be used as pesticidal traits in crop seeds, i.e., expressed in-plant rather than sprayed.
The company has two technology pillars:
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Target discovery and product design — sequences licensed from the Danforth Center and the company's own discovery work, including (per the Danforth Center's 2019 IN2 profile) novel mechanisms to target lepidopteran pests across a range of crops, and a high-throughput screening platform to identify biological insecticides.
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dsRNA manufacturing — the RNAgri platform acquired in June 2020, aimed at producing dsRNA at cost, yield and purity suitable for field application.
Company's own description
RNAissance Ag does not publish an annual report. Its most consistent self-description, repeated in the October 2022 CEO-appointment release, is that its primary focus is developing sprayable RNAi pesticides against pests such as diamondback moth, fall armyworm and several others, designed to be highly specific to the target pest, non-toxic to other organisms, and biodegradable, with additional applicability as seed traits. The 2019 IN2 cohort announcement described it as a biotechnology startup focused on delivering RNA-based insecticides for crop protection.
Business model and revenue model
Product vs. service vs. subscription vs. licensing revenue mix: not publicly disclosed.
Value-chain position
RNAissance sits at the discovery/development end of the crop-protection value chain: target identification → dsRNA design → manufacturing → formulation (with partners such as AgroSpheres) → regulatory registration (US EPA under FIFRA) → distribution to growers. It has internalized manufacturing (RNAgri) but has not been shown to own formulation, regulatory or distribution capabilities at scale.
Customer types and end-markets
Ultimate customers would be growers (via distributors/retailers) and potentially seed and crop-protection companies as licensees.
Independent characterization
RNAissance Ag is best understood as a small, regionally anchored (St. Louis/Kansas City) venture-development portfolio company whose public profile peaked in 2019–2022. Its technology thesis has been validated at the category level — the EPA's December 2023 registration of GreenLight Biosciences' Calantha (ledprona) proved that a sprayable dsRNA insecticide can be registered in the US — but no public source reviewed shows RNAissance itself having filed for or obtained a registration, closed a priced institutional round, or announced a commercial partnership since 2022. The absence of public newsflow from 2023 through October 2026 is itself an important finding.
Strategy
There is no annual report or investor day. Stated strategic themes, drawn from company and parent statements:
Initiatives in the last 24 months (Oct 2024 – Oct 2026): none publicly announced. ESG commitments, cost programs, and medium-term financial targets or guidance: not publicly disclosed.
Products & Services
No product has a disclosed brand name, EPA registration number, launch year, or price. The catalog below is the complete set of publicly described offerings.
Product Portfolio
| Program / offering | Description | Target customer | Stage / latest year | Pricing |
|---|---|---|---|---|
Diamondback moth (Plutella xylostella) sprayable RNAi | Lead program; DBM causes roughly USD 4B of crop losses annually per AgFunderNews and has evolved some resistance to common pesticides | Brassica/vegetable growers | Field trials planned 2020; a "decision" expected by mid-2022 (CB Insights); no registration found as of Oct 2026 | Not disclosed |
Fall armyworm (Spodoptera frugiperda) sprayable RNAi | Second lead program | Corn and other field-crop growers | Field trials planned 2020 | Not disclosed |
Colorado potato beetle (Leptinotarsa decemlineata) | Named pipeline target | Potato growers | Pipeline (Dec 2022) | Not disclosed |
"Several others" | Unnamed pest targets; the 2019 profile references lepidoptera on a wide range of crops | — | Pipeline | Not disclosed |
Seed-trait applications | dsRNA designs deployable as in-plant pesticidal traits | Seed companies (licensing) | Stated capability only | Not disclosed |
| Offering | Description | Specifications | Stage | Pricing |
|---|---|---|---|---|
Low-cost dsRNA production platform (ex-RNAgri) | Process combining molecular biology, microbiology and chemical engineering to produce high-purity dsRNA | RNAgri reportedly claimed sub-USD 1.00 per gram (Dealroom summary — not independently verified); MTEC describes the platform as laboratory scale | Laboratory scale | Not disclosed |
| Service | Description | Source |
|---|---|---|
Collaborative R&D partnerships | Joint RNAi product development | MTEC directory |
Entomology testing and efficacy evaluation | Bioassay and efficacy work | MTEC directory |
Financial Narrative
RNAissance Ag is a private LLC and publishes no income statement, balance sheet or cash-flow statement. All metrics below are not publicly disclosed; tables are retained (blank cells) for structural completeness and automated ingestion.
Margins and growth (%)
Revenue CAGR: not calculable. EPS and dividends per share are not applicable to an LLC.
What is known about funding
Commentary. The discrepancy between USD 0.99M and USD 6.28M is material and unresolved. Dealroom's listing of RNAgri's own history shows several small seed, early-VC and debt items (including USD 1.3M early VC and USD 0.667M seed), consistent with that interpretation. In any case, total capital raised is very small relative to the cost of taking a novel-mode-of-action biopesticide through EPA registration — GreenLight's Calantha review alone took more than four years. The CEO's 2022 framing emphasized biomanufacturing and commercialization, but no subsequent financing has been reported, implying either quiet parent funding, a slowdown in activity, or undisclosed strategic arrangements.
Financial Detail
Functional Unit Details
| Functional unit (analyst-defined) | Contents | Products/services | Revenue disclosure |
|---|---|---|---|
Biopesticide Development | Target discovery, dsRNA design, efficacy testing, field trials, regulatory | Sprayable RNAi insecticides (DBM, FAW, Colorado potato beetle, others); seed-trait designs | Not publicly disclosed |
Biomanufacturing (ex-RNAgri) | dsRNA production platform | Laboratory-scale low-cost dsRNA production | Not publicly disclosed |
Segment Revenue
| Segment | FY2023 | FY2024 | FY2025 |
|---|---|---|---|
Biopesticide Development revenue (USD Mn) | — | — | — |
Biomanufacturing revenue (USD Mn) | — | — | — |
Total revenue (USD Mn) | — | — | — |
Financial Analysis
| Metric | FY2021 | FY2022 | FY2023 | FY2024 | FY2025 |
|---|---|---|---|---|---|
Revenue (USD Mn) | — | — | — | — | — |
Gross profit (USD Mn) | — | — | — | — | — |
Operating income (USD Mn) | — | — | — | — | — |
EBITDA (USD Mn) | — | — | — | — | — |
Pre-tax income (USD Mn) | — | — | — | — | — |
Net income (USD Mn) | — | — | — | — | — |
EPS basic (USD) | — | — | — | — | — |
EPS diluted (USD) | — | — | — | — | — |
Dividends per share (USD) | — | — | — | — | — |
Financial Analysis — Gross margin
| Metric | FY2021 | FY2022 | FY2023 | FY2024 | FY2025 |
|---|---|---|---|---|---|
Gross margin (%) | — | — | — | — | — |
Operating margin (%) | — | — | — | — | — |
EBITDA margin (%) | — | — | — | — | — |
Net margin (%) | — | — | — | — | — |
Revenue growth YoY (%) | — | — | — | — | — |
Financial Analysis — Total assets
| Metric | FY2021 | FY2022 | FY2023 | FY2024 | FY2025 |
|---|---|---|---|---|---|
Total assets (USD Mn) | — | — | — | — | — |
Cash and equivalents (USD Mn) | — | — | — | — | — |
Short-term debt (USD Mn) | — | — | — | — | — |
Long-term debt (USD Mn) | — | — | — | — | — |
Net debt (USD Mn) | — | — | — | — | — |
Equity (USD Mn) | — | — | — | — | — |
Goodwill and intangibles (USD Mn) | — | — | — | — | — |
Working capital (USD Mn) | — | — | — | — | — |
Financial Analysis — Operating cash flow
| Metric | FY2021 | FY2022 | FY2023 | FY2024 | FY2025 |
|---|---|---|---|---|---|
Operating cash flow (USD Mn) | — | — | — | — | — |
Capex (USD Mn) | — | — | — | — | — |
Free cash flow (USD Mn) | — | — | — | — | — |
Dividends paid (USD Mn) | — | — | — | — | — |
Buybacks (USD Mn) | — | — | — | — | — |
Financial Analysis — ROE
| Ratio | FY2021 | FY2022 | FY2023 | FY2024 | FY2025 |
|---|---|---|---|---|---|
ROE (%) | — | — | — | — | — |
ROA (%) | — | — | — | — | — |
ROIC (%) | — | — | — | — | — |
Current ratio (x) | — | — | — | — | — |
Debt to equity (x) | — | — | — | — | — |
Net debt to EBITDA (x) | — | — | — | — | — |
Interest coverage (x) | — | — | — | — | — |
Asset turnover (x) | — | — | — | — | — |
Cash conversion cycle (days) | — | — | — | — | — |
Financial Analysis ()
| Item | Figure | Source | Note |
|---|---|---|---|
Total funding raised | USD 6.28M | PitchBook | Conflicts with CB Insights |
Total funding raised | USD 0.99M | CB Insights | Single "unattributed VC" round, dated roughly six years before the profile snapshot (≈2019–2020) |
Wells Fargo IN2 award | Up to USD 0.25M | IN2 announcement, 2019 | Non-dilutive |
Named investors | TechAccel (Technology Acceleration Partners), Donald Danforth Plant Science Center, Neo Technology Ventures, Wells Fargo Innovation Incubator | CB Insights | — |
Named investors (additional) | Allen Angel Capital, BioGenerator Ventures, BRDG Park, Cultivation Capital, Missouri Technology Corporation (5 of 8 listed) | PitchBook | Several of these were RNAgri investors pre-acquisition (Allen Angel Capital, BioGenerator i6, MTC IDEA grant), which may explain the higher PitchBook total if RNAgri funding history was rolled up |
Last valuation | Not publicly disclosed | — | — |
Geographic Revenue
| Region | FY2023 | FY2024 | FY2025 |
|---|---|---|---|
United States revenue (USD Mn) | — | — | — |
Rest of world revenue (USD Mn) | — | — | — |
Capital Markets
| Item | Status |
|---|---|
Share price performance (1/3/5-year) | Not applicable — no listed equity |
Valuation multiples (P/E, EV/EBITDA, EV/Sales, P/B) | Not applicable |
Last private valuation | Not publicly disclosed |
Analyst consensus | None — no sell-side coverage |
Dividend history / policy | — |
Buyback authorizations | — |
Credit ratings (Moody's / S&P / Fitch) | Not rated |
Debt maturity profile | Not publicly disclosed |
Capital Markets Data
| Metric | FY2019 | FY2020 | FY2021 | FY2022 | FY2023 |
|---|---|---|---|---|---|
Disclosed external funding (USD Mn) | — | — | — | — | — |
Non-dilutive awards (USD Mn) | 0.25 | — | — | — | — |
Analyst Conclusions
Management guidance: none published. Consensus growth expectations: none (no coverage).
Bull case
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Validated category, differentiated targets. EPA's December 2023 registration of Calantha proved the sprayable-dsRNA regulatory pathway; RNAissance's focus on lepidopterans (DBM, FAW) addresses larger, more resistance-prone markets than GreenLight's beetle-focused first product, if its claimed novel mechanisms deliver field efficacy.
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Asset value to strategics. Exclusive Danforth IP, three patent filings, and an owned dsRNA manufacturing platform form a compact, acquirable package for a major seeking lepidopteran RNAi sequences or trait leads.
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Experienced commercial leadership and channel links. A former Monsanto Science Fellow as CEO and a board member at Wilbur-Ellis's venture arm create plausible routes to licensing or distribution.
Bear case
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Capital inadequacy. At USD 1–6M raised, the company is far below what a multi-year EPA registration and commercial scale-up typically require.
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Silence as signal. No disclosed news since December 2022, an unresolved mid-2022 "decision", and possibly falling headcount suggest stalled progress or reduced operations.
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Competitive and technical headwinds. GreenLight has first-mover advantage, lepidopteran RNAi efficacy is technically difficult, and growers have cheap, effective Bt and chemical alternatives for DBM and FAW.
Analyst verdict
RNAissance Ag is a genuine but very small and opaque participant in one of agriculture's most promising new technology categories. Its origins are credible: an exclusive license to RNAi discoveries made at the Donald Danforth Plant Science Center, incubation by TechAccel, early validation through the Wells Fargo IN2 program, and a 2020 acquisition that gave it in-house dsRNA manufacturing. Its scientific thesis — species-specific, biodegradable insecticides that offer a new mode of action against resistant pests — has since been vindicated at the category level by the EPA's registration of a competitor's sprayable dsRNA product in December 2023, which also created a dedicated IRAC mode-of-action group.
However, the company's own trajectory has become difficult to assess. Public disclosure effectively stops in late 2022, with the appointment of an experienced ex-Monsanto CEO and a 14-person team. Since then, no registration, financing, partnership, or product milestone has been reported, a mid-2022 regulatory "decision" remains unexplained, aggregator headcount figures are lower, and total capital raised — USD 0.99M or USD 6.28M depending on source — is modest relative to the multi-year, multi-million-dollar burden of bringing a novel biopesticide to market. Meanwhile, the better-capitalized first mover has a product on shelves.
The input classification of this entity as a public company is incorrect; it is a privately held, parent-controlled LLC with no financial disclosure, so no valuation or equity view is possible. For a strategic or venture reader, the asset is best viewed as an option: Danforth-derived lepidopteran RNAi IP plus a manufacturing platform, potentially valuable to a seed or crop-protection major, but whose current operating status, runway, and field-efficacy data must be verified directly with the company and TechAccel before any decision. Priority diligence items: registration status, 2020 field-trial results, license terms with the Danforth Center, current headcount and cash runway.
Sources
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Donald Danforth Plant Science Center — "TechAccel and Danforth Center Launch New Company to Control Insects" (24 Jan 2019): https://www.danforthcenter.org/news/techaccel-and-danforth-center-launch-new-company-to-control-insects/
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Donald Danforth Plant Science Center — "Battling Bugs: Danforth Center Founded Startup RNAissance Ag…" (Dec 2022): https://www.danforthcenter.org/news/battling-bugs-danforth-center-founded-startup-rnaissance-ag-offers-targeted-sustainable-solutions-in-a-warming-world/
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Donald Danforth Plant Science Center — "Meet Our IN2 Cohort: RNAissance Ag" (2019): https://danforthcenter.org/news/meet-our-in2-cohort-rnaissance-ag
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AgFunderNews — "TechAccel subsidiary RNAissance Ag acquires RNAgri to boost manufacturing capacity" (18 Jun 2020): https://agfundernews.com/techaccel-subsidiary-rnaissance-acquires-rnagri-to-boost-manufacturing-capacity
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AgFunderNews — "TechAccel and Donald Danforth Center Launch RNAissance…" (Jan 2019): https://agfundernews.com/techaccel-and-donald-danforth-center-found-rnaissance-to-create-environmentally-friendly-pesticides.html
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SeedToday — "TechAccel and Danforth Center launch new company to control insects" (Jan 2019): https://www.seedtoday.com/article/161835/techaccel-and-danforth-center-launch-new-company-to-control-insects
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Startland News — "Biopesticide AgTech building toward RNAissance with TechAccel cultivation" (29 Jan 2019): https://www.startlandnews.com/2019/01/rnaissance-ag-techaccel
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Startland News — "RNAi-tech startup takes lead from psychotropics, medical cannabis veteran with new CEO pick" (20 Oct 2022): https://www.startlandnews.com/2022/10/steve-meyer-rnaissance-ag-2
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AgriBusiness Global — "RNAissance Ag Names Agri-Tech Leader Steve Meyer New CEO" (Oct 2022): https://www.agribusinessglobal.com/biopesticides/rnaissance-ag-names-agri-tech-leader-steve-meyer-new-ceo/
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Oil & Gas 360 (reprint) — "RNAissance Ag Named to Wells Fargo Innovation Incubator Cohort…" (2019): https://www.oilandgas360.com/rnaissance-ag-named-to-wells-fargo-innovation-incubator-cohort-focused-on-sustainable-agriculture/
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Farm Progress — "Advance pest control technology" (11 Feb 2019): https://www.farmprogress.com/technology/advance-pest-control-technology
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CB Insights — RNAissance Ag profile and people: https://www.cbinsights.com/company/rnaissance-ag ; https://www.cbinsights.com/company/rnaissance-ag/people
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PitchBook — RNAiSSANCE AG profile: https://pitchbook.com/profiles/company/264946-87
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SPEEDA Edge — RNAissance profile: https://sp-edge.com/companies/795172
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MTEC directory — RNAissance: https://mtec-sc.org/life-sciences/rnaissance
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Dealroom — RNAgri: https://app.dealroom.co/companies/rnagri
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MarketScreener/Zonebourse — Brad Fabbri insider profile: https://zonebourse.com/insider/BRAD-FABBRI-A3EUII
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US EPA — Calantha/ledprona registration (21 Dec 2023) and amendments (6 Mar 2025, 10 Apr 2025): https://www3.epa.gov/pesticides/chem_search/ppls/094614-00002-20231221.pdf ; https://www3.epa.gov/pesticides/chem_search/ppls/094614-00002-20250306.pdf ; https://www3.epa.gov/pesticides/chem_search/ppls/094614-00002-20250410.pdf
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New Ag International — "GreenLight Biosciences Secures EPA Registration for New Bioinsecticide" (9 Jan 2024): https://www.newaginternational.com/biocontrol/greenlight-biosciences-secures-epa-registration-for-new-bioinsecticide/
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Potato Business — GreenLight Calantha registration and first order: https://www.potatobusiness.com/?p=25176
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Minnesota Department of Agriculture — Ledprona review (Mar 2024): https://www.mda.state.mn.us/sites/default/files/docs/2024-03/ledpronareview.pdf
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Frontiers in Physiology (2022) — cost-effective dsRNA production: https://pmc.ncbi.nlm.nih.gov/articles/PMC9043282
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Frontiers Research Topic 33960 — dsRNA-based insecticides: https://www.frontiersin.org/researchtopic/33960
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Fruit Growers News — Renaissance BioScience Corp. (name-confusion reference, Nov 2022): https://fruitgrowersnews.com/news/bioengineering-company-brings-on-ag-tech-expert
Executive Leadership
Executive Leadership Team
| Name | Title | Tenure | Prior roles | Education | Compensation | Source |
|---|---|---|---|---|---|---|
Steven (Steve) Meyer | Chief Executive Officer | Oct 2022 – present (no departure reported) | COO, Lucy Scientific Discovery Inc. (British Columbia; cGMP manufacturer of psychotropic compounds); co-founder and CEO, Heya Wellness (St. Charles, MO; medical cannabis); roughly 16 years at Monsanto (now Bayer Crop Science) in scientific and commercial roles, including insect-control discovery work leading to appointment as Monsanto Science Fellow, and operations lead for North America Knowledge Transfer | MS Biological Sciences, Washington University; BS Biological Sciences, Lindenwood University | Not publicly disclosed | Oct 2022 release (AgriBusiness Global, Startland News) |
Bala P. Venkata, PhD | Co-founder; scientific founder (Danforth Center senior research scientist, entomologist) | 2019 – present (listed as current founder by CB Insights) | Danforth Center; discoverer of the underlying RNAi approach (2017) | PhD (field not specified in sources) | Not publicly disclosed | Danforth Center; CB Insights |
Nigel Taylor, PhD | Co-founder / co-inventor | 2019 – role today not disclosed | Associate Member and Dorothy J. King Distinguished Investigator, Danforth Center | PhD | Not publicly disclosed | Launch release 2019 |
Board of Directors
| Name | Role | Affiliation | Source |
|---|---|---|---|
Michael Helmstetter, PhD | Chairman | Founder and president (and CEO) of TechAccel; former CRO executive | Oct 2022 release; CB Insights |
Brett Morris | Director | Previously principal at TechAccel (2020 spokesperson for the RNAgri deal); later Managing Director, Cavallo Ventures (venture arm of Wilbur-Ellis) per CB Insights | CB Insights; AgFunderNews 2020 |
Brad Fabbri, PhD | Director | Chief Scientific Officer, TechAccel (since 2016); President, Fabbri Group; advisor to The Yield Lab | MarketScreener/Zonebourse |
Board & Management Changes
| Date | Change | Context |
|---|---|---|
Oct 2022 | Steve Meyer appointed CEO | First disclosed standalone CEO; mandate framed by the chair as driving both biomanufacturing and biopesticide development to commercial success |
2023–Oct 2026 | None publicly reported | — |
Major Shareholders
| Holder | Stake | Source |
|---|---|---|
TechAccel LLC (controlling) | Not publicly disclosed; described as parent of a subsidiary | AgFunderNews 2020; Oct 2022 release |
Donald Danforth Plant Science Center | Not disclosed (investor and licensor) | CB Insights |
Neo Technology Ventures; Wells Fargo IN2; BioGenerator Ventures; Cultivation Capital; Allen Angel Capital; Missouri Technology Corporation; BRDG Park | Not disclosed | CB Insights; PitchBook |
Competitive Landscape
Key Competitors
| Competitor | Segment overlap | Approach | Status / positioning vs. RNAissance |
|---|---|---|---|
GreenLight Biosciences (US; taken private 2023) | Sprayable dsRNA insecticides; RNA manufacturing | Cell-free RNA production; Calantha (ledprona) for Colorado potato beetle; Varroa mite product submitted to EPA early 2023 | Clear category leader and first mover with an EPA-registered product; also a historical collaborator and fellow TechAccel portfolio company |
Bayer Crop Science | RNAi seed traits (corn rootworm, MON87411 / SmartStax PRO) | In-plant RNAi traits | Incumbent proof of RNAi in agriculture; potential licensee or competitor for trait applications |
Syngenta | Crop protection; RNA-based research | Large R&D in biologicals and RNA | Scale incumbent; distribution power |
Corteva Agriscience | Insecticides, traits, biologicals | Chemistry, traits, biologicals | Competes for the same DBM/FAW spend |
AgroSpheres (US) | Formulation/encapsulation of biologicals, including RNA | Bioparticle encapsulation | Partner and potential competitor in RNA delivery |
Renaissance BioScience Corp. (Canada) | RNA production and oral delivery for crop protection | Yeast-based RNA platform | Similar thesis; name confusion risk |
Trillium Ag and other dsRNA startups | Sprayable RNAi | dsRNA products | — |
Vestaron (US) | Bioinsecticides | Peptide-based insecticides | Competes for "safe new mode of action" positioning in lepidopteran control |
Conventional chemistry (e.g., diamides, spinosyns from multiple manufacturers) | DBM and FAW control | Synthetic insecticides | Entrenched, low-cost, broad-spectrum incumbents |
Bt biologicals (multiple suppliers) | Lepidopteran control | Bacillus thuringiensis sprays and traits | Established biological alternative for caterpillars |
Peer Comparison FY2025
| Metric | RNAissance Ag | GreenLight Biosciences | Bayer Crop Science | Syngenta |
|---|---|---|---|---|
Registered sprayable RNAi product | None found | Yes (Calantha, Dec 2023) | No sprayable (trait-based RNAi) | — |
Revenue | Not publicly disclosed | Not publicly disclosed (private since 2023) | Not reproduced (division of listed Bayer AG) | Not reproduced |
Growth / margins / R&D intensity | Not publicly disclosed | Not publicly disclosed | Not reproduced | Not reproduced |
Employees | 9–14 (sources conflict) | — | Large multinational | Large multinational |
Recent Developments
Finding: * No material company-specific developments for RNAissance Ag were identified in public sources (news, press releases, trade press, aggregator news feeds) for the 18 months to 7 October 2026. The minimum of 25 entries cannot be met without fabrication. The register below records the most recent verifiable company events and relevant industry events, clearly labelled.
Layoffs/hiring, litigation, regulatory actions, guidance revisions: none reported.
