Market Size (2017)
$1.08B
Vertical: HealthcareBase Year: 2017
Market Size (2017)
$1.08B
Projected (2023)
$2.11B
CAGR (2015–2023)
11.0%
Key Players
10+
Amniotic membrane is a combination of tissues and cells which helps in wound healing by acting as foundation for re-growth of soft tissues. These are most widely used in eye surgery as a biological bandage to heal or replace damaged eye tissue. Increasing aging patient population, the rise in amniotic membrane-based transplantations globally, and rising disease awareness drive the growth of the global amniotic membrane market. However, stringent regulatory policies may hamper the growth of the market.
The global amniotic membrane market is expected to register a CAGR of 12.16% during the forecast period from 2018 to 2023. In 2017, the market was led by the Americas with 37.6% share, followed by Europe and Asia-Pacific with shares of 31.9% and 23.4%, respectively.
The global amniotic membrane market has been segmented based on the type, application, end user, and region.
Based on the type, the cryopreservation amniotic membrane segment accounted for the largest market share of 56.5% in 2017, with a market value of USD 609.44 million, which is projected to register a CAGR of 10.44% during the forecast period.
Based on application, the surgical wounds segment accounted for the largest market share of 21.8% in 2017, with a market value of USD 235.58 million, which is projected to register a CAGR of 12.47% during the forecast period.
Based on end user, the hospital & clinics segment accounted for the largest market share of 38.9% in 2017, with a market value of USD 420.25 million, which is projected to register a CAGR of 13.39% during the forecast period.
The Amniotic Membrane Market market is projected to grow at a CAGR of 11.0% from 2015 to 2023.
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View Subscription PlansAmniotic Membrane Market
Historical performance and future projections (2020–2030, USD Billion)
Market Size (USD Mn)
Amniotic membrane is the innermost layer of the placenta, and it consists of thick basement membrane and avascular stromal matrix. Amniotic membrane is used as a dressing in different surgical procedures. In the field of ophthalmology, this is used as tissue bandage for cornea infections and to reconstruct ocular surfaces for various procedures. Moreover, increasing awareness regarding the benefit of amniotic membrane in individuals as well as healthcare professionals will create more demand for amniotic membrane products. Hence it helps to boost the growth of the global amniotic membrane market.
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View Subscription PlansThis report applies a rigorous multi-stage research process combining primary interviews, secondary data sources, and bottom-up market modelling to ensure accuracy and completeness across all segments and geographies.
Base Year
2017
Historical Period
2015 – 2016
Forecast Period
2018 – 2023
Primary Interviews
150+
Historical data (2015–2017) and forecast period (2017–2023)
Our research process spans primary interviews with industry stakeholders combined with comprehensive secondary data analysis, validated through triangulation across multiple independent sources.
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View Subscription PlansThe global amniotic membrane market seems to be a very lucrative, attractive, and profitable market, both for existing as well as new entrants. At the same time, intense rivalry among existing competitors has been observed. Our analysis revealed that market players had adopted different strategies to increase their business and position in the global amniotic membrane market. In recent years, strategic movements by major players were product launches, mergers and acquisitions, and expansions, which have been used as market penetration strategies and to reduce competition. The major players in the global amniotic membrane market are MiMedx, Osiris Therapeutics, Integra LifeSciences, Alliqua BioMedical, Inc., Skye Biologics Inc., and others.
Companies are now entering into acquisitions to neutralize growing competition from customers, competitors, and to tackle the changing market dynamics.
Company Share Analysis
There are numerous players operating in this market all over the globe. Most of these players exist in the American and European regions. There are a lot of large and small market players available in the market which provide a wide range of products for various applications. As there are many large and small players in the market, the market shares of these players are very differentiated. Some of the major players who provide amniotic membranes include MiMedx, Applied Biologics, Alliqua BioMedical, Inc., Organogenesis Inc., Integra LifeSciences, Skye Biologics Inc., Amniox Medical, Inc., Katena Products. Inc., Human Regenerative Technologies, LLC, Amnio Technology, LLC, Osiris Therapeutics, and others.
MiMedx, Osiris Therapeutics, Integra LifeSciences, and Alliqua BioMedical, are top players in the global amniotic membrane market, contributing all most 48.7% of the total global market.
Bargaining Power of Suppliers
Bargaining power of suppliers in the global amniotic membrane market is medium. The suppliers in the global amniotic membrane industry are the hospitals and specialty clinics that derive amniotic membrane from the placenta of the fetus. Currently, a moderate number of suppliers are present in the market due to stringent government regulations and high opportunities. Currently, major players are accounting for a significant share of the market. Switching cost of the suppliers is medium because suppliers tend to enter into long-term associations, partnership, and deals with the companies that sell products made using amniotic membranes.
Bargaining Power of Buyers
The bargaining power of the buyers is medium in the global amniotic membrane market due to the presence of a moderate number of providers of amniotic membrane-based products. Also, the market has a large number of buyers comprising hospitals, clinics, ambulatory surgical centers, and other specialty clinics. Also, buyers prefer products manufactured by known brands. However, there are very few big brands present in the market. Because of this, the bargaining power of the buyers is medium.
Threat of New Entrants
The threat of new entrants in the global amniotic membrane market is medium. Any company trying to enter the market is required to accept the mandatory regulatory standards issued by government authorities. The market is also characterized by a high degree of brand loyalty where establishing a brand name is difficult for newcomers. Moreover, if a company desires to survive in the market, they have to introduce innovative products for various therapeutic applications and product innovation requires a large amount of investment as well as time. Also, there are very strict government regulations which a company has to follow in the market. However, the presence of huge opportunities in the market has increased the threat of new entrants to the market.
Threat of Substitutes
The threat of substitutes in the global amniotic membrane market is low to medium. Currently, amniotic membranes do not have any direct substitutes. However, stem cell technology can be used in a few of the application areas of amniotic membranes. Hence, the threat of substitutes is low to medium in the amniotic membrane market, due to very less availability of options in the market.
Intense Rivalry
The degree of competition in the global amniotic membrane market is medium. Many companies are present in this market. These players have a moderate degree of product differentiation. They are introducing innovative and more affordable products in the market. These factors slightly increase the rivalry in the amniotic membrane market. Companies involved in amniotic membrane market are trying to acquire new players in the market and merge with major players to survive in the market. Big brands are trying to acquire small players of the market, to create a competitive edge, which is creating a medium level of rivalry in the market.
Market estimates by geography (2023)
InsightAmericas leads with $759.61M by 2023, while Asia Pacific is projected to grow fastest at a 12.0% CAGR.
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View Subscription Plans| REGION | 2015 | 2017 | 2023 | CAGR | SHARE |
|---|---|---|---|---|---|
| Middle East and Africa | $64.97M | $93.40M | $151.97M | 11.2% | 7% |
| Americas | $348.62M | $487.90M | $759.61M | 10.2% | 36% |
| Asia Pacific | $210.45M | $312.82M | $521.02M | 12.0% | 25% |
| Europe | $290.97M | $421.16M | $681.71M | 11.2% | 32% |
| Total | $915.01M | $1.32B | $2.11B | 11.0% | 100% |
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View Subscription PlansTotal Market Size
$2.11B
| APPLICATION | REVENUE ($B) | GROWTH RATE | MARKET PENETRATION |
|---|---|---|---|
| Cryopreservation Amniotic Membrane | $1.09B | 9.4% | 52% |
| Lyophilized Amniotic Membrane | $1.02B | 13.0% | 48% |
* Revenue projections based on 2025 estimates. Growth rates represent CAGR 2024–2030. Market penetration indicates current adoption rate within addressable market segments.
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Analytical insights on Amniotic Membrane Market covering market dynamics, competitive landscape, and strategic outlook.
The Amniotic Membrane Market market is projected to reach $2.11B by 2023, growing at 11.0% CAGR. The Cryopreservation Amniotic Membrane segment holds the largest share.
Amniotic membrane is a combination of tissues and cells which are used for biological dressing and helps in wound healing. It has anti-inflammatory, anti-bacterial, anti-immunogenic, and anti-fibrotic properties. In the early 1900s, the human placental membrane was used as a skin substitute. The amniotic membrane was first used in ophthalmology in 1940 for the treatment of ocular burn wound. Over the last 25 years, thousands of ocular surgical procedures were carried out with the help of the amniotic membrane to treat various ocular disorders. These are used in various surgical procedures as a biological dressing. These amniotic membranes are used in numerous surgical procedures such as biological bandages for burns, non-healing diabetic and venous ulcers, and repair of the abdominal hernia. The amniotic membrane is also used in eye surgeries as a biological bandage to heal damaged tissues. Over 2 million people worldwide receive treatments with amniotic membrane transplant for eye surgeries. However, factors such as the rising amniotic membrane transplantation and rapid growth in the geriatric population may hamper the growth of the market during the forecast period.
Amniotic membrane is a biological tissue that is used as a graft for corneal and conjunctival reconstruction in various ocular surface diseases. It possesses anti-scarring and anti-inflammatory properties. The amniotic membrane is also used as a biological patch, bandage, and is also used to treat acute inflammatory disorders. As per the survey carried out by the National Centre for Biotechnology Information (NCBI) in 2016, a total of 771 amniotic membrane surgeries were performed in 2016 at the University Eye Hospital Tübingen. The overall prevalence of eye disease is approximately 14% in the general population. Pterygium is a wing-shaped superficial overgrowth on the ocular surface which is characterized by inflammation and invasion of the corneal surface. Whereas, the pterygium disease is common among adults in the US. A significant increase in amniotic membrane transplantation had been observed from 2001 to 2016. As per the Center of Ophthalmology Report 2016, the mean number of amniotic membrane transplantation was 48 per year. Moreover, increasing efforts by manufacturers on R&D activities to expand the product portfolio to include injections, pre-filled syringes, and medicines to meet the rising demand for amniotic membrane are some of the factors expected to drive the revenue growth of the target market.
Developing economies pose an opportunity for various markets as they have undeveloped research and development sectors owing to which they are unable to address upcoming health challenges. Despite huge demand, the African region is dependent on imported medicines and other health technologies. Although there is a high requirement for treatment, poor economic conditions lead to the slow growth of the healthcare industry within the African region. As per the statistics of NCBI in 2016, around 180 patients from West China Hospital who underwent excision of skin lesions treated with the help of amniotic membrane lived in low- and middle-income countries. This huge population affected with the ocular disease in developing countries serves as a strong opportunity for key players operating in the amniotic membrane market.
Amniotic membrane is used for many years as an adjuvant for tissues healing. Its use has been continued to expand to other fields of orthopedics, urology, gynecology, plastic surgery, dentistry, and wound care. But these are most widely used in ocular surgery. The high cost of amniotic membrane remains one of the major barriers in the successful treatment of ocular diseases. The cost of the treatment increases exponentially with the increasing demand for an amniotic membrane for the treatment of various ocular diseases. The venous ulcers treatment costs even higher than other ocular diseases. Furthermore, healthcare reengineering paradigms that manage increasing co-morbidities such as skin disease, diabetes, and dry eye disease should offer additional potential for cost reductions in the coming years.
1.1 Pricing Analysis
Pricing is among the most important factors for any product to withstand in the market. Pricing of any product or service depends on many factors which include the cost of raw material used for the product, technology used, cost of research and development, labor charges and many other costs. Pricing plays an important role in the business to make key strategies. The amniotic membrane is a narrow range market and includes less variety of products which includes products of different prices. The cost of the product varies by technology, application, and types of product.
Amniotic membranes are used in laboratories, ambulatory surgical centers, and many hospitals to perform surgeries. The companies are focused on the use of specific technologies, to reduce the cost of the product. These products vary by its applications, and the preservation method used. So, the major companies are focusing on developing cost-effective products to grow their business in developing region such as Asia-Pacific and the Middle East.
Investment in the market highlights the growth parameters of the industry. Patents and approvals, reimbursement policies, the growth of the products based on amniotic membrane, and the complications caused due to various factors define the potential of the market. There is a huge demand or potential in the amniotic membrane market, and most of the applications are related to surgeries.
Innovation and development in the amniotic membrane market benefit both the manufacturers as well as investors, to make huge profits. Therefore, a revolution in technologies for new product offering will provide investment opportunities in the future.
Faster healing of surgical wounds using amniotic membranes
Surgical wounds generally do not heal fast. Amniotic membranes lead to a faster recovery by healing these wounds in a shorter period. So, as the number of surgeries is increasing, demand for amniotic membranes is also increasing, hence creating more investment opportunities for the global amniotic membrane market in the near future.
Rising use of amniotic membranes in ophthalmology
The increasing application of amniotic membranes in ophthalmological procedures for treatment of eye disorders like cataract and other such disorders is boosting the market growth, which in turn is creating immense opportunities for companies to invest in the market.
According to a report published by the European Pharmaceutical Review in November 2018, total US investment in medical and health R&D increased by 27% between 2013 and 2017. These investments are majorly made by the federal government and the healthcare industry, and it boosts the investment opportunities in the global amniotic membrane market.
There are various existing players manufacturing amniotic membrane-based products for the indications mentioned above, so there can be innovation done in the existing products like the product size of amniotic allografts and efficacy of amniotic membranes can be modified. Another investment opportunity is to manufacture the products, with add-on features. Companies can do business by outsourcing the manufacturing of products. So, this may reduce the cost of manufacturing.
Near-term growth will likely concentrate in modular bioreactor lines and closed-system media workflows that shorten validation cycles while preserving batch traceability.
Partnerships between CDMOs and instrumentation vendors should accelerate standard datasets for comparability across sites, improving forecasting models used in capacity planning.
Longer horizon, organoid and microphysiological adoption may reshape segment mix; teams that invest early in assay interoperability and cloud QC hooks are better positioned to capture upside without fragmenting their analytics stack.
Profiles of 103 companies operating in the Amniotic Membrane Market market, including revenue, employee count, and market positioning where available.
Showing 103 of 103 companies
MiMedx
Company Headquarters: Georgia, US Founded: 2008 Workforce: 1000+ Company Working: MiMedx is a biopharmaceutical company which develops, manufactures, and markets regenerative biologics using human placental allografts for multiple sectors of healthcare. The company processes human placental tissue utilizing its proprietary PURION process methodology, among other processes, to produce safe and effective allografts by employing aseptic processing techniques in addition to terminal sterilization. MiMedx’s portfolio includes products based on amniotic membrane, umbilical cord, placental ECM, and amniotic fluid.
Skye Biologics Inc
Company Headquarters: California, U.S. Founded: 2006 Workforce: 200+ Company Working: Skye Biologics Inc. (Skye) develops and manufactures Biological Extracellular Matrix (BioECM) products designed to assist the body in its natural ability to remodel properly. These products are formulated to protect and augment degenerated or damaged tissues in surgical repairs and non-operative therapy as a potential alternative to surgery.
Applied Biologics
Company Headquarters: Arizona, US Founded: 2010 Company Working: Applied Biologics is a manufacturer of wound care products which are derived from amnion. It is a fully integrated life sciences company that provides research, product development, manufacturing and distribution of medical technologies. It is an outstanding worldwide source of regenerative medicine technology, clinical research, education, and training for the constantly evolving healthcare industry. Its sole focus is on products based on amniotic membranes.
Novavax, Inc.
Company Headquarters: Maryland, US Founded: 1987 Workforce: ~2,500 Company Working: Novavax, Inc. is a biotechnology company that commercializes and develops vaccines to prevent a wide range of infectious diseases. It designs recombinant nanoparticle vaccine technology that produces a strong immune response against a variety of pathogens. It is partnered with leading biopharma organizations, government agencies, research institutions, and foundations, namely the Coalition for Epidemic Preparedness Innovations (US), the Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense (US), the Serum Institute of India Pvt. Ltd. (India), SK Bioscience (South Korea), CPL Biological (India), and Takeda Pharmaceuticals (US). It has seven research and manufacturing facilities. It has presence in regions namely North America, Europe, and the Middle East and Africa
Cleveland Biolabs, Inc
Company Headquarters: New York, US Founded: 2003 Workforce: ~150 Company Working: Cleveland Biolabs, Inc. is an innovative biopharmaceutical company developing products to address immune system diseases and serious medical needs. It is specialized in offering products such as radiation injury products, immune-oncology, and orphan drugs. It has nine product candidates in its pipeline that have been developing directly through itself or its wholly owned companies, namely Incuron, LLC (US) and Panacela Labs, Inc. (US). It has a proprietary platform, namely the Advanced Immunomodulating Multi-Receptor System (AIMS) platform, which is designed to restore immune homeostasis. Moreover, it has collaboration with government agencies which supports the advanced development and procurement of new medical countermeasures including drugs, vaccines, diagnostics, and medical supplies in order to protect public health from chemical, biological, radiological, and nuclear threats.
SIGA Technologies
Company Headquarters: New York, US Founded: 1995 Workforce: ~50 Company Working: SIGA Technologies (SIGA) is a pharmaceutical business at the commercialization stage that develops and offers antiviral treatments for smallpox, monkeypox, cowpox, and vaccinia complications. The company has an established research and development collaboration with US federal entities. It provides countermeasures to the Strategic National Stockpile (SNS) and the Department of Defense (DoD). TPOXX ("oral TPOXX," also known as "tecovirimat" in certain overseas markets) is the Company's lead product, which it distributes to the US government and international governments (including government-affiliated entities). In addition, the Company sells TPOXX intravenous formulation ("IV TPOXX") to the US Government
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