Market Size (2021)
$741.00M
Vertical: HealthcareBase Year: 202112 Sections
Market Size (2021)
$741.00M
Projected (2030)
$1.25B
CAGR (2018–2030)
5.5%
Key Players
9+
The growth of the esophageal squamous cell carcinoma market is attributed to the increasing prevalence of achalasia, increased research activities and product approvals, and rising health awareness. However, the high cost of treatment and side effects of esophageal cancer drugs is anticipated to hamper the market growth.
The Esophagous Squamous Cell Carcinoma Market market is projected to grow at a CAGR of 5.5% from 2018 to 2030.
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View Subscription PlansEsophagous Squamous Cell Carcinoma Market
Historical performance and future projections (2020–2030, USD Billion)
Market Size (USD Mn)
Esophageal cancer is a disease in which the tissues of the esophagus develop cancerous cells. Esophageal cancer risk factors include smoking, drinking too much alcohol, and Barrett's esophagus. Weight loss and discomfort or difficulty swallowing are symptoms and signs of esophageal cancer. Treatments such as chemotherapy, immunotherapy, and targeted drug therapies are available for esophageal cancer. Some drugs are used in combinations and are approved by the Food and Drug Administration (FDA) such as XELIRI combinations of capecitabine and irinotecan hydrochloride.
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View Subscription PlansThis report applies a rigorous multi-stage research process combining primary interviews, secondary data sources, and bottom-up market modelling to ensure accuracy and completeness across all segments and geographies.
Base Year
2021
Historical Period
2018 – 2020
Forecast Period
2022 – 2030
Primary Interviews
150+
Historical data (2018–2021) and forecast period (2021–2030)
Our research process spans primary interviews with industry stakeholders combined with comprehensive secondary data analysis, validated through triangulation across multiple independent sources.
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View Subscription PlansThe global esophageal squamous cell carcinoma market is distinguished by the presence of numerous global, regional, and local players catering to the increasing prevalence of achalasia, the rising prevalence of squamous cell carcinoma, and increased research activities. However, the high cost of treatment and side effects of esophageal cancer drugs may hamper the growth of the global esophageal squamous cell carcinoma market. The major players have adopted a strategy of obtaining regulatory approval from government agencies for their products, services, and agreements to broaden their reach and reduce operational costs.
The global esophageal squamous cell carcinoma market is extremely competitive, with players competing, partnering, and investing heavily in research and development to gain a significant market share. The market is moderately fragmented with rising competition, product launches, increasing collaborative partnerships, and other strategic decisions to achieve operational efficiency. For instance, in June 2022, Eli Lilly and Company (US) and Innovent Biologics, Inc. (China), a biopharmaceutical company, announced approval for TYVYT (sintilimab injection) for first-line treatment for esophageal squamous cell carcinoma by the Center for Drug Evaluation (CDE) of China's National Medical Products Administration (NMPA).
The business model developed by manufacturers in the global esophageal squamous cell carcinoma market includes offering high-quality products. The growth of prominent industry players is dependent on various factors, such as market conditions, government support, and industry development. Key players in the esophageal squamous cell carcinoma market are focusing on offering high-quality products to their customers. It is also projected that the rise in clinical trials will boost the market's growth in the upcoming future.
With respect to the current scope of the report, F. Hoffmann-La Roche Ltd (Switzerland) is the top player in the global esophageal squamous cell carcinoma market due to its high-quality products offering and high preference for its products by customers. Novartis AG (Switzerland) is the second-largest player, followed by AstraZeneca (UK), Glaxosmithkline Plc (UK), and Eli Lilly and Company (US). Other key players contributing to the market growth include Chia Tai Tianqing Pharmaceutical Group Co. Ltd. (China) and Seagen Inc. (US) among others.
Threat of New Entrants
The threat of new entrants in the global esophageal squamous cell carcinoma market is relatively low. the global esophageal squamous cell carcinoma market is growing rapidly, hence attracting many new entrants who are looking to make a profit. However, the entry barriers are high due to the high cost of developing new treatments and the complexity of the regulatory environment. The development of new drugs and therapies requires significant financial resources, and the regulatory process can be long and arduous which decreases the threat of new entrants to some level. Companies aim to increase their market share and capture the market share which is mostly untouched by major players. Hence, the threat of new entrants in the global esophageal squamous cell carcinoma market is expected to be relatively low.
Bargaining Power of Suppliers
The bargaining power of suppliers in the global esophageal squamous cell carcinoma market is moderate as there is an increase in demand for raw materials by pharmaceutical companies. However, the number of suppliers is also high in the market, which is slightly decreasing the bargaining power of suppliers due to low switching costs. Additionally, the supply of raw materials is disrupted to some level due to the logistics issues that the world is facing currently, which in turn increases the bargaining power of suppliers.
Threat of Substitutes
The threat of substitutes in the esophageal squamous cell carcinoma in R&D market is high. For esophageal squamous cell carcinoma, there are few effective alternatives to the treatments such as electrocoagulation, endoscopic resection, etc. currently available, patients and healthcare providers are unlikely to switch to untested or unproven therapies. However, advances in technology and research may lead to new treatments that could potentially serve as substitutes in the future. There are several players offering similar products at competitive prices, which increases the threat of substitutes between players.
Bargaining Power of Buyers
The bargaining power of buyers is moderate in the global esophageal squamous cell carcinoma market. Patients and healthcare providers have a significant amount of power when it comes to choosing which treatments to use, as there are many different options available. Additionally, many patients and healthcare providers are becoming increasingly cost-conscious, which can drive down prices and increase competition between manufacturers. Hence, this lowers the bargaining power of buyers to some extent.
Intensity of Rivalry
The degree of competition in the esophageal squamous cell carcinoma market is high owing to there are several key players in the market, each with their own products and pipelines. Additionally, the market is constantly evolving as new drugs and therapies are developed and approved, leading to intense competition for market share. Companies must continue to invest in research and development to stay competitive and meet the changing needs of patients and healthcare providers. Such factors might increase the level of product differentiation and will support the sales of the manufacturers.
Market estimates by geography (2030)
InsightNorth America leads with $503.42M by 2030, while Asia Pacific is projected to grow fastest at a 6.9% CAGR.
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View Subscription Plans| REGION | 2018 | 2021 | 2030 | CAGR | SHARE |
|---|---|---|---|---|---|
| North America | $261.62M | $345.81M | $503.42M | 5.6% | 40% |
| Europe | $177.93M | $225.21M | $313.56M | 4.8% | 25% |
| Asia Pacific | $136.14M | $193.75M | $302.28M | 6.9% | 24% |
| Rest of the World | $81.74M | $100.15M | $133.97M | 4.2% | 11% |
| Total | $657.43M | $864.92M | $1.25B | 5.5% | 100% |
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View Subscription PlansTotal Market Size
$1.25B
| APPLICATION | REVENUE ($B) | GROWTH RATE | MARKET PENETRATION |
|---|---|---|---|
| Treatment | $656.50M | 4.5% | 52% |
| Diagnosis | $596.73M | 6.8% | 48% |
* Revenue projections based on 2025 estimates. Growth rates represent CAGR 2024–2030. Market penetration indicates current adoption rate within addressable market segments.
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Analytical insights on Esophagous Squamous Cell Carcinoma Market covering market dynamics, competitive landscape, and strategic outlook.
The Esophagous Squamous Cell Carcinoma Market market is projected to reach $1.25B by 2030, growing at 5.5% CAGR. The Treatment segment holds the largest share.
The global market space for Esophageal Squamous Cell Carcinoma has been identified as stable and slow yet steadily moving over the past 2-3 years. Further, we estimate the market to showcase similar trends and growth pattern over the next 5-6 years. Please note that the said scenario is realistic and is most likely to occur unless there are any groundbreaking disruptions or activities in the market.
The expected growth in market can be attributed to the growing increasing prevalence of Achalasia, increased research activities & product approvals, and rising public awareness. However, the market is also held back by high cost of treatment and side effects of esophageal cancer drugs. The cost factor in association with the average affordability hampers the growth projectile of the market. Nevertheless, it is anticipated that the rise in clinical trials will create lucrative opportunities for the players operating in the global market.
The increasing prevalence of achalasia will aid market growth because achalasia patients have a higher risk of esophageal squamous cell carcinoma than the general population. According to a journal, Annals of Esophagus, Achalasia affects 9 to 10 people per 100,000 people worldwide each year. Furthermore, achalasia can cause food retention, which can lead to bacterial overgrowth, irritation, and chronic inflammation, a pathophysiological process that has been proposed to lead to squamous cell carcinoma. Moreover, two recent meta-analyses found that the incidence rate of squamous cell carcinoma in patients with achalasia ranges from 1.36/1,000 patients-years to 3.12/1,000 patients-years, with risks of 1.5% and 2.8%, respectively. Moreover, according to the International Agency for Research on Cancer, these rates are 15 and 34 times higher, respectively, than the risk of esophageal squamous cell carcinoma in the general population. Therefore, increasing prevalence of achalasia will directly affect the market growth of global esophageal squamous cell carcinoma positively.
Rise in clinical trials conducted in developed and developing countries for novel drugs for the treatment of esophageal cancer will create lucrative market opportunities. Furthermore, several new targeted agents and immunotherapies are being tested in clinical trials. Approximately 20% of cancer clinical trials fail due to insufficient patient enrollment, despite patients' strong willingness to participate. To address this issue, American Cancer Society Cancer Action Network (ACS CAN) has identified several barriers and is working on implementing a set of consensus recommendations to make it easier for patients to enroll in an appropriate clinical trial. Moreover, according to the US Food and Drugs Administration (FDA) and other sources, the pharmaceutical industry is currently spending more than USD 38.0 billion on preclinical and clinical development of oncology therapy products. For instance, in December 2018, the National Cancer Center Hospital in Tokyo began a clinical trial comparing combination therapy with induction DCF (docetaxel plus cisplatin and 5-fluorouracil) versus definitive chemo-radiotherapy for locally advanced thoracic esophageal carcinoma.
The high cost of treatment for esophageal squamous cell carcinoma will hamper the growth of the market. Moreover, according to American Cancer Society, more research is needed to determine the costs and benefits of esophageal squamous cell carcinoma prevention treatment in high-risk populations. Furthermore, cancer costs are estimated in a variety of ways, including direct medical costs (the total of all health-care expenditures) and indirect costs (such as lost earnings due to illness or premature death). According to the National Cancer Institute, cancer-related direct medical costs in the US were USD 183 billion in 2015 and are expected to rise to USD 246 billion by 2030, a 34% increase based solely on population growth and aging. The projection, however, is likely an underestimation due to the rising cost of treatment; for instance, the list price for many prescription medicines is more than USD 100,000 per year. Furthermore, lack of health insurance coverage is strongly linked to medical financial hardship and prevents many people from receiving optimal cancer prevention, detection, and treatment. Hence, high cost of treatment for esophageal squamous cell carcinoma will hamper the growth of the market.
The COVID-19 pandemic has significantly and negatively impacted the Global Esophageal squamous cell carcinoma market. During the pandemic decrease in the demand for Esophageal Squamous Cell Carcinoma (ESCC) treatments. This is due to various factors, such as the redirection of healthcare resources towards the management of COVID-19 patients, the suspension of elective procedures, and the reluctance of patients to visit healthcare facilities for fear of contracting the virus. As a result, many patients have delayed or postponed their treatments, which has led to a decline in the demand for ESCC treatments. This had a negative impact on the market.
The pandemic has impacted the business environment for several organizations worldwide. The supply chain in the global esophageal squamous cell carcinoma market is the key to fulfilling customer demands. In addition, due to the pandemic, several countries have imposed import and export limitations. This has also affected the healthcare industry as many countries are dependent on other countries for raw material supply and technology transfer. However, regulatory bodies took significant initiatives to ensure efficient supply chain management during the pandemic. The closure of manufacturing facilities and transportation networks has also affected the production and distribution of medicines. To overcome such challenges, key players also expanded their manufacturing capabilities to meet demand.
The COVID-19 pandemic had moderate impacted on players operating in the market. For instance, in October 2020, the company Bristol-Myers Squibb (US) has developed a drug called OPDIVO (nivolumab) for the treatment of ESCC. However, the COVID-19 pandemic has affected the company's supply chain, resulting in delays in the availability of some of its drugs. Nevertheless, as the effects of the pandemic started to diminish as the number of cases declined, majority of the populations got vaccinated and return to normalcy was observed in 2021. Hence, the pandemic had a moderate impact on the market players.
Profiles of 101 companies operating in the Esophagous Squamous Cell Carcinoma Market market, including revenue, employee count, and market positioning where available.
Showing 101 of 101 companies
Seagen Inc.
Company Headquarters: Washington, US Founded: 1997 Workforce: ~ 2,700 Company Working: Seagen Inc., a biotechnology company, develops and commercializes therapies for the treatment of cancer in the United States and internationally. The company was formerly known as Seattle Genetics, Inc. and changed its name to Seagen Inc. in October 2020. Seagen Inc. It offers antibody-drug conjugates (ADCs), including Padcevtm (enfortumab vedotin-ejfv), which is used to treat metastatic urothelial cancers, Adcetris (brentuximab vedotin), which is used to treat Hodgkin's lymphoma, T-cell lymphomas, and CD30-expressing lymphomas. (Tucat) Tukysa. Seagen's therapies are based on antibody-drug conjugate technology that utilizes the targeting ability of monoclonal antibodies to deliver cell-killing agents directly to cancer cells. Additionally, Seagen also licenses its antibody-drug conjugate technology to several biotechnology and pharmaceutical companies. Seagen serves customers on a global scale.
Novartis AG
Company Headquarters: Basel, Switzerland Founded: 1996 Workforce: ~126,000 Company Working: Novartis AG (Novartis) was established in 1996 through a merger of Ciba-Geigy and Sandoz. Novartis and its preceding companies have been known to develop innovative products which can be traced back to over 250 years. The company focuses on the development and marketing of products that contribute to human progress through advances in science and health. It provides products that find applications in cancer, cardio-metabolic, immunology and dermatology, ophthalmology, neuroscience, and respiratory disease areas. Its Sandoz segment offers active ingredients and finished dosage forms of pharmaceuticals in cardiovascular, dermatology, central nervous system (CNS), gastrointestinal and hormonal therapy, metabolism, oncology, ophthalmic, pain, and respiratory areas, among others. It also provides active pharmaceutical ingredients (API) and intermediates primarily antibiotics, protein- or other biotechnology-based products including biosimilars, and biotechnology manufacturing services.
Novavax, Inc.
Company Headquarters: Maryland, US Founded: 1987 Workforce: ~2,500 Company Working: Novavax, Inc. is a biotechnology company that commercializes and develops vaccines to prevent a wide range of infectious diseases. It designs recombinant nanoparticle vaccine technology that produces a strong immune response against a variety of pathogens. It is partnered with leading biopharma organizations, government agencies, research institutions, and foundations, namely the Coalition for Epidemic Preparedness Innovations (US), the Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense (US), the Serum Institute of India Pvt. Ltd. (India), SK Bioscience (South Korea), CPL Biological (India), and Takeda Pharmaceuticals (US). It has seven research and manufacturing facilities. It has presence in regions namely North America, Europe, and the Middle East and Africa
Cleveland Biolabs, Inc
Company Headquarters: New York, US Founded: 2003 Workforce: ~150 Company Working: Cleveland Biolabs, Inc. is an innovative biopharmaceutical company developing products to address immune system diseases and serious medical needs. It is specialized in offering products such as radiation injury products, immune-oncology, and orphan drugs. It has nine product candidates in its pipeline that have been developing directly through itself or its wholly owned companies, namely Incuron, LLC (US) and Panacela Labs, Inc. (US). It has a proprietary platform, namely the Advanced Immunomodulating Multi-Receptor System (AIMS) platform, which is designed to restore immune homeostasis. Moreover, it has collaboration with government agencies which supports the advanced development and procurement of new medical countermeasures including drugs, vaccines, diagnostics, and medical supplies in order to protect public health from chemical, biological, radiological, and nuclear threats.
SIGA Technologies
Company Headquarters: New York, US Founded: 1995 Workforce: ~50 Company Working: SIGA Technologies (SIGA) is a pharmaceutical business at the commercialization stage that develops and offers antiviral treatments for smallpox, monkeypox, cowpox, and vaccinia complications. The company has an established research and development collaboration with US federal entities. It provides countermeasures to the Strategic National Stockpile (SNS) and the Department of Defense (DoD). TPOXX ("oral TPOXX," also known as "tecovirimat" in certain overseas markets) is the Company's lead product, which it distributes to the US government and international governments (including government-affiliated entities). In addition, the Company sells TPOXX intravenous formulation ("IV TPOXX") to the US Government
Altimmune
Company Headquarters: Maryland, US Founded: 1997 Workforce: ~50 Company Working: Altimmune is a clinical-stage biopharmaceutical business focusing on treating obesity and liver illnesses. The business is working on HepTcell, an immunotherapeutic drug aimed at providing a functional cure for chronic hepatitis B. The company was formed through the merger of PharmAthene, Inc. ("PharmAthene") with the company formerly known as Altimmune
12 interactive charts drawn from the Esophagous Squamous Cell Carcinoma Market dataset — market size, regional splits and each segment breakdown. Open one to read its full data table and download it.
Global Esophagous Squamous Cell Carcinoma Market By End User Others Parent
Global Esophagous Squamous Cell Carcinoma Market By End User
Global Esophagous Squamous Cell Carcinoma Market By Diagnosis And Treatment
Global Esophagous Squamous Cell Carcinoma Market Middle-East, Africa and Latin-America Of Rest Of The World
Global Esophagous Squamous Cell Carcinoma Market China, India, Japan, Australia, South Korea and Rest Of Asia Pacific By Country
Global Esophagous Squamous Cell Carcinoma Market Germany, United Kingdom, France, Italy, Spain and Rest Of Europe By Country
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